Vîrgolici Bogdana, Stoian Irina, Muscurel Corina, Mărăcine Magda, Popescu Laura, Moraru C, Dinu Veronica
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Intern Med. 2009;47(3):279-87.
Recent studies on cataract formation focus on a primary role of systemic oxidative stress, generated outside the lens. Plasma inflammatory markers are associated with senile cataract.
The aim of this study was to find correlations between blood oxidative stress markers and some inflammatory plasma markers in cataractous patients.
The blood samples were collected from 38 patients (aged 50 to 80). Patients were subdivided according to two criteria. Considering age criteria, presenile and senile cataract groups were formed. According to the absence or presence of other ocular comorbidities (age-related macular degeneration, glaucoma), pure cataract and nonpure cataract groups were constituted. Fifteen age and sex matched healthy subjects were selected for the control group.
In our study, for all groups of patients, the measured markers of oxidative stress were modified vs. control values. Plasma antioxidant capacity, plasma antioxidant "gap", cholesterol and albumin/globulin levels were significantly decreased while RBC SOD activity, RBC catalase activity and plasma ceruloplasmin were significantly increased. Inflammatory markers, ceruloplasmin and albumin/globulins were correlated with different parameters of oxidative stress.
The blood redox values and the level of some inflammatory markers demonstrate that senile cataract is a systemic disease with an inflammatory component.
近期关于白内障形成的研究聚焦于晶状体外部产生的全身性氧化应激的主要作用。血浆炎症标志物与老年性白内障相关。
本研究旨在探寻白内障患者血液氧化应激标志物与某些血浆炎症标志物之间的相关性。
采集了38例年龄在50至80岁患者的血样。患者根据两个标准进行细分。按照年龄标准，分为早老性和老年性白内障组。根据是否存在其他眼部合并症（年龄相关性黄斑变性、青光眼），分为单纯性白内障组和非单纯性白内障组。选取15名年龄和性别匹配的健康受试者作为对照组。
在我们的研究中，对于所有患者组，所测氧化应激标志物与对照值相比均有改变。血浆抗氧化能力、血浆抗氧化“差值”、胆固醇和白蛋白/球蛋白水平显著降低，而红细胞超氧化物歧化酶活性、红细胞过氧化氢酶活性和血浆铜蓝蛋白显著升高。炎症标志物、铜蓝蛋白和白蛋白/球蛋白与氧化应激的不同参数相关。
血液氧化还原值和某些炎症标志物水平表明，老年性白内障是一种伴有炎症成分的全身性疾病。
