Department of Psychiatry, National Taiwan University Hospital, No. 7 Chung Shan S. Road, Taipei 10002, Taiwan.
Psychiatry Clin Neurosci. 2010 Apr;64(2):202-6. doi: 10.1111/j.1440-1819.2010.02070.x.
The feasible intervention strategy at the prodromal state of psychosis is under debate. We report nine subjects clinically in a putative prodromal state of psychosis who responded to low-dose aripiprazole within the first week of medication. We conjecture that the pathophysiological processes might be easier to modify by antipsychotics in the prodromal state and we believe a short-term low-dose trial of antipsychotic agents is a convenient option for subjects at ultra high risk of psychosis. We urge specific attention to monitor the dissolution of psychotic-like symptoms carefully in order to have a better understanding of the pathogenesis and pharmacotherapy in the inception of psychosis.
在精神病前驱期可行的干预策略仍存在争议。我们报告了 9 例处于精神病前驱期的临床患者，他们在用药的第一周内对低剂量阿立哌唑有反应。我们推测在前驱期使用抗精神病药物可能更容易改变病理生理过程，我们相信对于处于精神病超高风险的患者，短期低剂量抗精神病药物试验是一种方便的选择。我们强烈建议特别注意监测类精神病症状的缓解情况，以便更好地了解精神病发病机制和药物治疗。
