Rauchs G, Harand C, Bertran F, Desgranges B, Eustache F
Unité de recherche U923, Inserm-EPHE-Université de Caen Basse-Normandie, GIP Cyceron, and Service des explorations fonctionnelles neurologiques, CHU de Caen, boulevard Becquerel, BP 5229, 14074 Caen cedex, France.
Rev Neurol (Paris). 2010 Nov;166(11):873-81. doi: 10.1016/j.neurol.2010.03.021. Epub 2010 May 5.
A large body of evidence indicates that sleep favors memory consolidation.
This process would occur, mainly during slow-wave sleep, by means of a dialogue between the hippocampus and neocortical areas. Low levels of acetylcholine and cortisol are also needed to favor the transfer of memory traces toward the neocortex, where they will be stored for the long-term.
The aim of this article is, first, to give an overview of studies conducted in young healthy subjects and underpinning the hypothesis that sleep is involved in memory consolidation. Then, we will investigate the potential links between changes in sleep architecture and episodic memory impairment in both aging and Alzheimer's disease. Finally, we will see how these results can affect clinical practice.
Sleep-dependent memory consolidation is impaired both in aging and Alzheimer's disease. These findings suggest the importance of taking into account sleep when assessing memory function in patients.
大量证据表明睡眠有助于记忆巩固。
这一过程主要在慢波睡眠期间发生，通过海马体与新皮质区域之间的对话实现。还需要低水平的乙酰胆碱和皮质醇来促进记忆痕迹向新皮质的转移，记忆痕迹将在新皮质中长期存储。
本文的目的首先是概述在年轻健康受试者中进行的研究，并支持睡眠参与记忆巩固这一假说。然后，我们将研究睡眠结构变化与衰老和阿尔茨海默病中情景记忆损害之间的潜在联系。最后，我们将探讨这些结果如何影响临床实践。
衰老和阿尔茨海默病中依赖睡眠的记忆巩固均受损。这些发现表明在评估患者记忆功能时考虑睡眠的重要性。
