Centre for Rheumatology Research, Landspitali, Hringbraut - University Hospital, Reykjavik 101, Iceland.
Ann Rheum Dis. 2010 Jul;69(7):1346-8. doi: 10.1136/ard.2009.125914. Epub 2010 May 6.
To elucidate the familiality of ankylosing spondylitis (AS) in Iceland.
The Icelandic genealogy database and population-wide data on all living Icelanders diagnosed as having AS (n=280), who previously had taken part in an epidemiological study on the prevalence of AS in Iceland, were included in the study. Identification of all interpatient relationships in the genealogy database allowed calculation of estimates of the RR for AS in the first-degree relatives (FDRs) to fourth-degree relatives of patients. For each AS proband, 1000 sets of matched Icelandic subjects in the genealogy database were used as controls.
FDRs, second-degree and third-degree relatives had RRs of 75.5, 20.2 and 3.5, respectively (all p values <0.0001), indicating a significantly increased risk for relatives of the patients with AS to develop AS, suggesting a strong heritable factor, while the fourth-degree relatives had a RR of 1.04 (p=0.476) for having AS.
Patients with AS in Iceland are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports on the familiality of AS, but the present study has more power and extends over larger familiar cohorts than previously reported.
阐明冰岛强直性脊柱炎（AS）的家族性。
本研究纳入了冰岛系谱数据库和所有被诊断患有 AS（n=280）的冰岛在世人群的全人群数据，这些患者曾参与过冰岛 AS 患病率的一项流行病学研究。系谱数据库中识别出所有患者间的关系，从而计算出患者一级至四级亲属患 AS 的相对风险（RR）。对于每个 AS 先证者，系谱数据库中的 1000 组匹配的冰岛对照者被用作对照。
一级亲属、二级亲属和三级亲属的 RR 分别为 75.5、20.2 和 3.5（均 p<0.0001），表明患者亲属患 AS 的风险显著增加，提示存在强烈的遗传因素，而四级亲属患 AS 的 RR 为 1.04（p=0.476）。
冰岛的 AS 患者彼此之间的相关性明显强于随机抽样对照者。这与之前关于 AS 家族性的报告一致，但本研究的效力更强，并且涉及的家族性队列比之前的报告更大。
