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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Int J Biochem. 1991;23(3):361-3. doi: 10.1016/0020-711x(91)90119-8.

The effect of administering triamcinolone acetonide (10 mg/kg/day), 6 consecutive s.c. injections given daily, on plasma free amino acids and urinary urea output was studied in rabbits. 2. The total free amino acids in plasma decreased significantly from day 2 while ammonia increased significantly only on day 2, glutamine, lysine and branched amino acids increased significantly from day 3 or 5. 3. The output of urinary urea increased significantly from day 3. 4. These findings suggest the inhibition of protein synthesis observed in steroid myopathy may result from a decrease in the amino acid pool in skeletal muscle.

研究了连续6天每天皮下注射曲安奈德（10毫克/千克/天）对家兔血浆游离氨基酸和尿尿素排出量的影响。2. 血浆中总游离氨基酸从第2天起显著下降，而氨仅在第2天显著增加，谷氨酰胺、赖氨酸和支链氨基酸从第3天或第5天起显著增加。3. 尿尿素排出量从第3天起显著增加。4. 这些发现表明，类固醇肌病中观察到的蛋白质合成抑制可能是由于骨骼肌中氨基酸池减少所致。

Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Int J Biochem. 1991;23(3):361-3. doi: 10.1016/0020-711x(91)90119-8.

The effect of administering triamcinolone acetonide (10 mg/kg/day), 6 consecutive s.c. injections given daily, on plasma free amino acids and urinary urea output was studied in rabbits. 2. The total free amino acids in plasma decreased significantly from day 2 while ammonia increased significantly only on day 2, glutamine, lysine and branched amino acids increased significantly from day 3 or 5. 3. The output of urinary urea increased significantly from day 3. 4. These findings suggest the inhibition of protein synthesis observed in steroid myopathy may result from a decrease in the amino acid pool in skeletal muscle.

研究了连续6天每天皮下注射曲安奈德（10毫克/千克/天）对家兔血浆游离氨基酸和尿尿素排出量的影响。2. 血浆中总游离氨基酸从第2天起显著下降，而氨仅在第2天显著增加，谷氨酰胺、赖氨酸和支链氨基酸从第3天或第5天起显著增加。3. 尿尿素排出量从第3天起显著增加。4. 这些发现表明，类固醇肌病中观察到的蛋白质合成抑制可能是由于骨骼肌中氨基酸池减少所致。