Nat Med. 2010 May;16(5):523-5. doi: 10.1038/nm0510-523.
Approximately 5% of people that are hospitalized for any reason develop acute kidney failure, which, in some cases, progresses to a chronic condition resulting in fibrosis of the kidney and permanent changes in the organ’s function. Two new studies suggest that cell cycle arrest of epithelial cells and epigenetic modifications have key roles in the switch to chronic disease (pages 535–543 and 544–550).
约 5%的因任何原因住院的人会发展为急性肾衰竭,在某些情况下,急性肾衰竭会进展为慢性疾病,导致肾脏纤维化和器官功能的永久性改变。两项新的研究表明,上皮细胞的细胞周期停滞和表观遗传修饰在向慢性疾病的转变中起着关键作用(第 535-543 页和第 544-550 页)。