Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Key Laboratory of Prevention and Management of Chronic Kidney Diseases of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Int J Mol Sci. 2023 Aug 31;24(17):13558. doi: 10.3390/ijms241713558.
Inflammation is a crucial pathological feature in cancers and kidney diseases, playing a significant role in disease progression. Cyclin-dependent kinases CDK4 and CDK6 not only contribute to cell cycle progression but also participate in cell metabolism, immunogenicity and anti-tumor immune responses. Recently, CDK4/6 inhibitors have gained approval for investigational treatment of breast cancer and various other tumors. Kidney diseases and cancers commonly exhibit characteristic pathological features, such as the involvement of inflammatory cells and persistent chronic inflammation. Remarkably, CDK4/6 inhibitors have demonstrated impressive efficacy in treating non-cancerous conditions, including certain kidney diseases. Current studies have identified the renoprotective effect of CDK4/6 inhibitors, presenting a novel idea and potential direction for treating kidney diseases in the future. In this review, we briefly reviewed the cell cycle in mammals and the role of CDK4/6 in regulating it. We then provided an introduction to CDK4/6 inhibitors and their use in cancer treatment. Additionally, we emphasized the importance of these inhibitors in the treatment of kidney diseases. Collectively, growing evidence demonstrates that targeting CDK4 and CDK6 through CDK4/6 inhibitors might have therapeutic benefits in various cancers and kidney diseases and should be further explored in the future.
炎症是癌症和肾脏疾病的重要病理特征，在疾病进展中起着重要作用。细胞周期蛋白依赖性激酶 CDK4 和 CDK6 不仅有助于细胞周期的进展，还参与细胞代谢、免疫原性和抗肿瘤免疫反应。最近，CDK4/6 抑制剂已被批准用于研究性治疗乳腺癌和各种其他肿瘤。肾脏疾病和癌症通常表现出特征性的病理特征，如炎症细胞的参与和持续的慢性炎症。值得注意的是，CDK4/6 抑制剂在治疗非癌性疾病方面显示出令人印象深刻的疗效，为未来治疗肾脏疾病提供了一个新的思路和潜在方向。在这篇综述中，我们简要回顾了哺乳动物的细胞周期以及 CDK4/6 在调节细胞周期中的作用。然后，我们介绍了 CDK4/6 抑制剂及其在癌症治疗中的应用。此外，我们强调了这些抑制剂在治疗肾脏疾病中的重要性。总之，越来越多的证据表明，通过 CDK4/6 抑制剂靶向 CDK4 和 CDK6 可能在各种癌症和肾脏疾病的治疗中具有治疗益处，未来应进一步探索。
