Velpandian T, Nirmal J, Gupta P, Vijayakumar A R, Ghose S
Department of Ocular Pharmacology and Pharmacy, All India Institute of Medical Sciences, New Delhi, India.
Methods Find Exp Clin Pharmacol. 2010 Apr;32(3):171-9. doi: 10.1358/mf.2010.32.3.1423888.
The present study evaluated the protective action of calcium dobesilate (CDO) in various experimental models of cataract. CDO was studied in hydrocortisone-induced cataract in developing chick embryos and selenite-induced cataract in pups. CDO anti-cataract activity was also evaluated after oral and topical application as eye drops in galactose (30%) fed rats. This study was further extended to evaluate the intraocular penetration of a single dose of 1% CDO (50 microL) in rabbits. CDO exhibited significant protection against cataract in experimental models and considerable penetration after single topical application. Anti-cataract activity may be due to its antioxidant as well as aldose reductase inhibitor properties. Further studies are in progress to evaluate its clinical efficacy in diabetic cataract.
本研究评估了羟苯磺酸钙（CDO）在各种白内障实验模型中的保护作用。在发育中的鸡胚氢化可的松诱导性白内障和幼崽亚硒酸盐诱导性白内障模型中对CDO进行了研究。还在喂食半乳糖（30%）的大鼠中通过口服和滴眼剂局部应用来评估CDO的抗白内障活性。本研究进一步扩展至评估单剂量1% CDO（50微升）在兔眼内的渗透情况。CDO在实验模型中对白内障表现出显著的保护作用，单次局部应用后有相当的渗透。抗白内障活性可能归因于其抗氧化以及醛糖还原酶抑制特性。正在进行进一步研究以评估其在糖尿病性白内障中的临床疗效。
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