Jue Zhenzhen, Xu Ziming, Yuen Vincent L, Chan Odessa Dik San, Yam Jason C
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong SAR, China.
Hong Kong Eye Hospital, Kowloon, Hong Kong SAR, China.
Graefes Arch Clin Exp Ophthalmol. 2025 Jan;263(1):147-156. doi: 10.1007/s00417-024-06592-w. Epub 2024 Aug 23.
The association between serum vitamin D level and cataract remains controversial. This study aims to evaluate the association between vitamin D level and cataract.
In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 30 August 2023 and 626 articles were screened. Four studies involving a total of 10,928 subjects with cataract and 10,117 control subjects met the inclusion criteria.
Decreased serum vitamin D level was associated with higher incidence of cataract (P = 0.047; MD: -4.87; 95%CI: [-9.67, -0.07]). In the subgroup analysis by sex, a significant association was found between serum vitamin D level and cataract in both male (P = 0.01, MD: -2.15,95%CI: [-3.83, -0.46]) and female (P < 0.01; MD: -6.67,95%CI: [-8.20, -5.14]).In the subgroup analysis by the types of cataract, significant association was found between serum vitamin D level and nuclear (P < 0.01; MD: -10.48; 95%CI: [-12.72, -8.24]) and posterior subcapsular cataract (P = 0.02; MD: -6.05; 95%CI: [-11.30, -0.80]) but not in cortical cataract (P = 0.14; MD: -6.74; 95%CI: [-15.70, 2.22]).
This meta-analysis revealed potential association between serum vitamin D level and cataract, more significant in female, and the subtypes of nuclear and posterior subcapsular cataract.
血清维生素D水平与白内障之间的关联仍存在争议。本研究旨在评估维生素D水平与白内障之间的关联。
在本研究中，检索了截至2023年8月30日的PubMed、科学网和EMBASE数据库中的文章，共筛选出626篇文章。四项研究共纳入10928例白内障患者和10117例对照者，符合纳入标准。
血清维生素D水平降低与白内障发病率较高相关（P = 0.047；MD：-4.87；95%CI：[-9.67，-0.07]）。在按性别进行的亚组分析中，男性（P = 0.01，MD：-2.15，95%CI：[-3.83，-0.46]）和女性（P < 0.01；MD：-6.67，95%CI：[-8.20，-5.14]）的血清维生素D水平与白内障之间均存在显著关联。在按白内障类型进行的亚组分析中，血清维生素D水平与核性白内障（P < 0.01；MD：-10.48；95%CI：[-12.72，-8.24]）和后囊下白内障（P = 0.02；MD：-6.05；95%CI：[-11.30，-0.80]）之间存在显著关联，但与皮质性白内障无关（P = 0.14；MD：-6.74；95%CI：[-15.70，2.22]）。
本荟萃分析揭示了血清维生素D水平与白内障之间的潜在关联，在女性以及核性和后囊下白内障亚型中更为显著。
