用于苯甲醛与重氮乙酸乙酯反应的高活性金基催化剂。

Highly active gold-based catalyst for the reaction of benzaldehyde with ethyl diazoacetate.

机构信息

Laboratorio de Catálisis Homogénea, Departamento de Química y Ciencia de los Materiales, Unidad Asociada al CSIC, Universidad de Huelva, Campus de El Carmen, 21007-Huelva, Spain.

出版信息

Chem Commun (Camb). 2009 Sep 14(34):5153-5. doi: 10.1039/b908233f. Epub 2009 Jul 16.

DOI:10.1039/b908233f

PMID:20448977

Abstract

The gold complex [IPrAu(NCMe)]BF(4) catalyzes the reaction of ethyl diazoacetate with benzaldehyde to give mixtures of ethyl 3-oxo-3-phenylpropanoate and ethyl 3-hydroxy-2-phenylacrylate in the first example of a group 11 metal-based catalyst for this transformation; the catalyst activity is improved by a factor of 2500 compared to those of previously reported iron-based catalysts.

摘要

金配合物 [IPrAu(NCMe)]BF(4) 催化了重氮乙酸乙酯与苯甲醛的反应，生成了 3-氧代-3-苯基丙酸乙酯和 3-羟基-2-苯基丙烯酸乙酯的混合物，这是首例用于该转化的第 11 族金属基催化剂；与之前报道的铁基催化剂相比，该催化剂的活性提高了 2500 倍。