铑催化的乙基重氮乙酸酯、H2O 和芳基亚胺的三组分反应中的组分匹配：β-芳基异丝氨酸衍生物的高非对映选择性一步合成。
Component match in rhodium catalyzed three-component reactions of ethyl diazoacetate, H2O and aryl imines: a highly diastereoselective one-step synthesis of beta-aryl isoserine derivatives.
机构信息
Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China.
出版信息
Org Biomol Chem. 2009 Dec 7;7(23):5028-33. doi: 10.1039/b915013g. Epub 2009 Oct 12.
DOI:10.1039/b915013g
PMID:19907795
Abstract
Water and ethyl diazoacetate were found to be matched components for generating highly reactive nucleophilic oxonium ylide in the presence of a dirhodium acetate catalyst. Simultaneous trapping of the oxonium ylide intermediate with aryl imines gave beta-aryl isoserine derivatives with high diastereoselectivity.
摘要
水和乙基重氮乙酸酯在醋酸二铑催化剂的存在下被发现是生成高反应性亲核氧翁叶立德的匹配组分。同时用芳基亚胺捕获氧翁叶立德中间体得到了具有高非对映选择性的β-芳基异丝氨酸衍生物。
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