含骨靶向基团的铂（II）化合物：合成、晶体结构和抗肿瘤活性。
Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity.
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
出版信息
Chem Commun (Camb). 2010 Feb 28;46(8):1212-4. doi: 10.1039/b922222g. Epub 2010 Jan 16.
DOI:10.1039/b922222g
PMID:20449253
Abstract
Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.
摘要
含有偕二膦酸酯部分的铂（II）配合物在有机溶剂和水溶液中都具有极好的溶解性，并对人骨肉瘤（MG-63）和卵巢癌细胞（COC1）显示出相当的细胞毒性，其凋亡途径与顺铂不同。
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