Sakurai Takeo, Kimura Akio, Yamada Megumi, Hayashi Yuichi, Tanaka Yuji, Hozumi Isao, Inuzuka Takashi
Department of Neurology and Geriatrics, Division of Neuroscience, Research Field of Medical Sciences, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
Brain Nerve. 2010 May;62(5):527-31.
A 46-year-old woman was diagnosed with having idiopathic aqueductal stenosis for which she underwent ventriculoperitoneal (V-P) shunting. One year after the surgery, she developed acute parkinsonism and sylvian aqueduct syndrome. Brain magnetic resonance imaging (MRI) did not reveal any signs of hydrocephalus and fluorodopa positron emission tomography (PET) did not reveal any decrease in accumulation of fluorodopa at the striatum. On admission, the Unified Parkinson Disease Rating Scale (UPDRS) (Part III) score was 30 points. The preliminary diagnosis was parkinsonism associated with V-P shunting: therefore, the levodopa dosage was increased from 200 mg/day to 600 mg/day. Thereafter, the symptoms of parkinsonism and the sylvian aqueduct syndrome markedly improved, and the UPDRS (Part III) score decreased. If such a patient presents without signs of hydrocephalus or shunt malfunction, dopaminergic medication should be used as the initial treatment.
一名46岁女性被诊断为患有特发性导水管狭窄,并因此接受了脑室腹腔分流术(V-P分流术)。术后一年,她出现了急性帕金森综合征和大脑外侧裂导水管综合征。脑部磁共振成像(MRI)未显示任何脑积水迹象,氟多巴正电子发射断层扫描(PET)未显示纹状体处氟多巴积聚有任何减少。入院时,统一帕金森病评定量表(UPDRS)(第三部分)评分为30分。初步诊断为与V-P分流术相关的帕金森综合征:因此,左旋多巴剂量从200毫克/天增加至600毫克/天。此后,帕金森综合征和大脑外侧裂导水管综合征的症状明显改善,UPDRS(第三部分)评分降低。如果此类患者没有脑积水或分流装置故障的迹象,应将多巴胺能药物作为初始治疗方法。