通过掩蔽邻苯醌与手性硝基二烯亲电试剂的杂[4+2]环加成反应策略合成光学纯的康杜胺。
Syntheses of optically pure conduramines via the strategy of hetero Diels-Alder reaction of masked o-benzoquinones with homochiral nitroso dienophiles.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
出版信息
Org Lett. 2010 Jun 4;12(11):2642-5. doi: 10.1021/ol100840n.
PMID:20450183
Abstract
Highly stereoselective hetero Diels-Alder reactions of masked o-benzoquinones (MOBs) with homochiral nitroso dienophiles are described along with their application in the syntheses of (+)-ent-conduramine F-1, (+)-conduramine E-1, (-)-conduramine A-1, (+)-conduramine A-1 tetraacetate, and (-)-ent-conduramine A-1 tetraacetate.
摘要
高立体选择性的杂 Diels-Alder 反应的掩蔽邻苯醌 (MOBs) 与同手性硝基烯亲二烯体描述，以及它们在 (+)-ent-conduramine F-1、(+)-conduramine E-1、(-)-conduramine A-1、(+)-conduramine A-1 四乙酸酯和 (-)-ent-conduramine A-1 四乙酸酯的合成中的应用。
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