Zhong Xu, Xiao Yi, Huang Rong
Department of Respiratory Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2010 Apr;32(2):162-6. doi: 10.3881/j.issn.1000-503X.2010.02.007.
To explore the influence of obstructive sleep apnea hypopnea syndrome (OSAHS) on endothelial function and autonomic modulation.
Electrocardiogram and beat-to-beat blood pressure from the radial artery were continuously recorded by polysomnography and applanation tonometry, respectively in OSAHS patients (OSAHS group, n=20) and obese controls (control group, n=20). Vascular endothelial function was evaluated by arterial augmentation index (AAI), and autonomic modulation was evaluated by heart rate variability (HRV) and blood pressure variability (BPV).
The baseline AAI and BPV low frequency (LF) were significantly higher in OSAHS group than in control group (P<0.05). Compared with the pre-sleep levels, systolic blood pressure, diastolic blood pressure, HRV LF, HRV LF/high frequency and BPV LF significantly increased after over-night sleeps in OSAHS group (P<0.001), while HRV high frequency significantly decreased (P<0.05).
OSAHS patients usually have endothelial dysfunction and autonomic modulation disorder, which are independently related with OSAHS.
探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对内皮功能和自主神经调节的影响。
通过多导睡眠图和压平式眼压计分别连续记录OSAHS患者（OSAHS组，n = 20）和肥胖对照者（对照组，n = 20）的心电图及桡动脉逐搏血压。通过动脉增强指数（AAI）评估血管内皮功能，通过心率变异性（HRV）和血压变异性（BPV）评估自主神经调节。
OSAHS组的基线AAI和BPV低频（LF）显著高于对照组（P < 0.05）。与睡前水平相比，OSAHS组患者过夜睡眠后收缩压、舒张压、HRV LF、HRV LF/高频和BPV LF显著升高（P < 0.001），而HRV高频显著降低（P < 0.05）。
OSAHS患者通常存在内皮功能障碍和自主神经调节紊乱，且这些与OSAHS独立相关。
