Theaker J M, Fletcher C D
Department of Histopathology, Southampton General Hospital, UK.
Histopathology. 1991 Mar;18(3):255-60. doi: 10.1111/j.1365-2559.1991.tb00834.x.
The clinical, light microscopic and immunohistochemical features of 14 heterotopic glial nodules are described. In keeping with previous experience, most cases were located around the nose and had been present since birth. However, several lesions presented as cutaneous nodules elsewhere and, in some, presentation was delayed into childhood or even adulthood. The histological diagnosis is usually uncomplicated, but we draw attention to a variant with a markedly sclerosed stroma in which the glial cells are relatively inconspicuous. Such lesions tend to be found in older subjects and can cause problems in diagnosis. We emphasize the value of immunohistochemical demonstration of glial fibrillary acidic protein in the diagnosis of these lesions, especially in the sclerotic variant. Other immunohistochemical features include the presence of axons in most cases and cell bodies in some, emphasizing the mixed nature of these lesions. A meningeal component could not be demonstrated immunohistochemically, even at the edge of the lesions.
本文描述了14个异位神经胶质结节的临床、光学显微镜和免疫组织化学特征。与以往经验一致，大多数病例位于鼻周，自出生即已存在。然而，有几例病变表现为其他部位的皮肤结节，部分病例直到儿童期甚至成年期才出现症状。组织学诊断通常并不复杂，但我们注意到一种伴有明显硬化基质的变异型，其中神经胶质细胞相对不明显。此类病变多见于年长患者，可能会导致诊断困难。我们强调免疫组织化学检测神经胶质纤维酸性蛋白在这些病变诊断中的价值，尤其是在硬化变异型中。其他免疫组织化学特征包括多数病例中存在轴突，部分病例中有细胞体，这突出了这些病变的混合性质。即使在病变边缘，免疫组织化学也未能显示出脑膜成分。
