Department of Neurosurgery, Hiroshima University, Hiroshima, Japan.
Epilepsy Res. 2010 Jun;90(1-2):121-31. doi: 10.1016/j.eplepsyres.2010.04.002. Epub 2010 May 6.
To compare and validate the gradient magnetic-field topography (GMFT) method of current source localization for understanding epileptic zones against equivalent current dipole (ECD) and intracranial video-EEG (IVEEG) data in patients with intractable neocortical epilepsy.
We used retrospective data from eight patients to determine GMFT at onset (O) and peak (P) of interictal magnetoencephalography (MEG) spikes and mapped GMFT(O) and GMFT(P) locations and distributions using 12 zones in unilateral hemisphere. We compared GMFT with ECD, ictal onset zones (IOZ) and interictal zones on IVEEG, and seizure outcomes.
We projected GMFT(Os) and (Ps) for all spikes on volume-rendered brain surfaces. We localized ECDs for 6-61% of spikes (mean, 28.4%). GMFT(Ps) (mean, 10.3 zones) extended over more zones than GMFT(Os) (6.3 zones) for each spike (p<0.01). The ECD distributions (2.3 zones) were almost equal to the zones of IOZ and surgical areas. GMFT(O) localizations distributed much more extensively than IOZs and surgical areas in three patients with residual seizures comparing with those in five seizure-free patiens.
We validate the potential of GMFT to study the distribution of MEG spikes. GMFT has an advantage in analyzing the cortical activity and propagation from MEG spikes in neocortical epilepsy.
比较和验证梯度磁场地形图（GMFT）方法用于定位致痫区，以了解难治性新皮质癫痫患者的电流源，该方法与等效电流偶极子（ECD）和颅内视频脑电图（IVEEG）数据相吻合。
我们使用 8 名患者的回顾性数据，在发作间期脑磁图（MEG）棘波的起始（O）和峰值（P）确定 GMFT，并使用单侧半球的 12 个区来绘制 GMFT（O）和 GMFT（P）的位置和分布。我们将 GMFT 与 ECD、IVEEG 的发作起始区（IOZ）和发作间期区以及发作结果进行比较。
我们将所有棘波的 GMFT（Os）和（Ps）投影到容积渲染脑表面上。我们对 6-61%的棘波（平均 28.4%）定位了 ECD。对于每个棘波，GMFT（Ps）（平均 10.3 个区）比 GMFT（Os）（6.3 个区）扩展到更多的区（p<0.01）。ECD 分布（2.3 个区）几乎与 IOZ 和手术区相等。与 5 例无发作患者相比，在 3 例仍有发作的患者中，GMFT（O）的定位分布比 IOZ 和手术区广泛得多。
我们验证了 GMFT 研究 MEG 棘波分布的潜力。GMFT 在分析新皮质癫痫中 MEG 棘波的皮质活动和传播方面具有优势。
