Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA.
Eur Psychiatry. 2010 Jun;25(5):268-71. doi: 10.1016/j.eurpsy.2010.01.009. Epub 2010 May 6.
Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
一些神经生物学系统的改变与自杀行为有关,包括 5-羟色胺能和去甲肾上腺素能系统以及下丘脑-垂体-肾上腺轴。这些系统功能的改变可能源于遗传和发育原因。生命早期的逆境对这些系统产生了发育影响,并持续到成年期。遗传差异也可能导致神经生物学系统功能的改变。此外,越来越多的人认为,包括通过表观遗传机制,生命早期逆境经历和遗传易感性的相互作用起着一定的作用。