Klein Annette M, Glaesmer Heide
Department für Frauen- und Kindermedizin, Klinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik des Kindes- und Jugendalters, Universitätsklinikum Leipzig, Liebigstraße 20a, Leipzig.
Psychother Psychosom Med Psychol. 2012 Mar-Apr;62(3-4):95-101. doi: 10.1055/s-0032-1306320. Epub 2012 Apr 2.
As demonstrated by numerous studies in quantitative and molecular genetics, genetic factors play an important role in the development of mental disorders. This review gives an overview on the methods and the available evidence from research in quantitative and molecular genetics of depressive disorders with a special focus on recent approaches, i.e. epigenetic research and gene environment interactions (with the example of the serotonin transporter gene 5-HTTLPR). The implications of the available evidence are discussed in the context of future research as well as of clinical practice.
正如定量遗传学和分子遗传学的众多研究所表明的那样，遗传因素在精神障碍的发展中起着重要作用。本综述概述了抑郁症定量遗传学和分子遗传学研究的方法及现有证据，特别关注近期的研究方法，即表观遗传学研究和基因-环境相互作用（以血清素转运体基因5-HTTLPR为例）。在未来研究及临床实践的背景下，对现有证据的意义进行了讨论。
