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经皮输精管注射冲洗术是否能提高免切开法输精管切除术术后早期无精子症的发生率:一项前瞻性、随机、对照研究。

Intraoperative distal vasal flushing--does it improve the rate of early azoospermia following no-scalpel vasectomy? A prospective, randomized, controlled study.

机构信息

Centre of Excellence for No-Scalpel Vasectomy and Department of Urology, CSM, Medical University (Upgraded King George's Medical College), Uttar Pradesh, India.

出版信息

Urology. 2010 Aug;76(2):341-4. doi: 10.1016/j.urology.2010.01.091. Epub 2010 May 7.

Abstract

OBJECTIVE

To assess the impact of intraoperative distal vasal flushing during no-scalpel vasectomy on hastening the sperm clearance from the vas deferens and subsequent postvasectomy time to azoospermia.

MATERIAL AND METHODS

A total of 906 men undergoing vasectomy at our center from October 2007 to August 2008 were included in this prospective, randomized, controlled study. Patients were alternately allocated to 1 of 2 groups. Group A were patients who underwent no scalpel vasectomy alone; Group B patients, in addition to no scalpel vasectomy, underwent flushing of the distal vasal segment with 30 mL of sterile water. Postvasectomy semen analysis was done at 4, 8, and 12 weeks. The age, operative time, number of ejaculations, and proportion of patients' azoospermic at 4, 8, and 12 weeks after vasectomy were compared between the 2 groups.

RESULTS

A total of 727 men were available for final analysis. A significantly higher proportion of patients in group B were azoospermic at 4 and 8 weeks when compared with group A (group B: 53.40% and 80.68%; group A: 33.86% and 49.6% at 4 and 8 weeks, respectively). There was no statistically significant difference in the mean age, operative time, and number of ejaculations between the 2 groups.

CONCLUSIONS

Distal vasal flushing with 30 mL of sterile water may shorten the time to azoospermia for between 20% and 30% of vasectomy patients. Thus, this procedure may be an option for some who choose the vasal flush to avoid the long duration of postvasectomy alternate contraceptive methods.

摘要

目的

评估在无切口输精管结扎术中进行术中远端输精管冲洗对加速输精管内精子清除和随后的无精症时间的影响。

材料和方法

本前瞻性、随机、对照研究共纳入 2007 年 10 月至 2008 年 8 月在我院行输精管结扎术的 906 例男性患者。患者被交替分配到 2 组中的 1 组。A 组为仅行无切口输精管结扎术的患者;B 组患者除行无切口输精管结扎术外,还对远端输精管段进行 30ml 无菌水冲洗。术后 4、8 和 12 周进行精液分析。比较两组患者的年龄、手术时间、射精次数以及术后 4、8 和 12 周的无精症比例。

结果

共 727 例男性患者可进行最终分析。与 A 组相比,B 组患者在术后 4 和 8 周时无精症的比例显著更高(B 组:53.40%和 80.68%;A 组:33.86%和 49.6%,分别在 4 和 8 周时)。两组患者的平均年龄、手术时间和射精次数无统计学差异。

结论

用 30ml 无菌水对远端输精管进行冲洗可能使 20%至 30%的输精管结扎术患者的无精症时间缩短。因此,对于选择输精管冲洗以避免术后较长时间的替代避孕方法的患者,该方法可能是一种选择。

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