Urology. 2011 Feb;77(2):335-6. doi: 10.1016/j.urology.2010.03.006. Epub 2010 May 7.
A 30-year-old man with a history of bilateral deep vein thromboses and recurrent penile ischemic episodes presented for distal penile amputation and skin graft. Despite suspicion, serologies indicated no hypercoagulable disorder. After surgery, the patient was bridged from enoxaparin to warfarin. Nine days after initiation of warfarin therapy, he developed necrotic arm ulcers, which were subsequently proved to be secondary to warfarin-induced skin necrosis.
一位 30 岁男性，有双侧深静脉血栓形成和反复阴茎缺血发作病史，前来接受阴茎远端截肢和植皮手术。尽管有怀疑，但血清学检查未提示存在高凝状态。手术后，患者从依诺肝素桥接到华法林。华法林治疗开始后 9 天，他出现坏死性臂溃疡，随后证实是华法林诱导的皮肤坏死所致。
