二吡咯并[def:mn]芘修饰的γ-环糊精对双链 DNA 的识别。
Double stranded DNA discrimination by di-pyrene modified gamma-cyclodextrin.
机构信息
Department of Material-Process and Applied Chemistry for Environments, Graduate School of Engineering and Resource Science, Akita University, Akita 010-8502, Japan.
出版信息
Bioorg Med Chem Lett. 2010 Jun 1;20(11):3240-3. doi: 10.1016/j.bmcl.2010.04.066. Epub 2010 Apr 18.
Neutral fluorescent active di-pyrene modified gamma-cyclodextrin (1) was synthesized in order to discriminate with single and double strand DNA (ssDNA and dsDNA, respectively) with high selectivity. The binding and selectivity of 1 for dsDNA was indicated by increase of the fluorescent intensity in an addition of dsDNA. On the other hand, an increase of fluorescent intensity of 1 was not recognized in an addition of ssDNA.
为了高选择性地区分单链 DNA（ssDNA）和双链 DNA（dsDNA），合成了中性荧光活性二芘修饰的γ-环糊精（1）。1 与 dsDNA 的结合和选择性通过加入 dsDNA 后荧光强度的增加来指示。另一方面，在加入 ssDNA 时，1 的荧光强度增加没有被识别。
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