Department of Genetics and Biochemistry, Clemson University, 217 Biosystems Research Complex, 51 New Cherry Street, Clemson, SC 29634, USA.
Trends Microbiol. 2010 Jul;18(7):323-30. doi: 10.1016/j.tim.2010.04.003. Epub 2010 May 6.
The re-emergence of dengue virus as a significant human pathogen has lead to an increasing need for effective antivirals. Development of therapeutic agents with the ability to attenuate both the duration and severity of disease in patients after infection is particularly desirable in dengue endemic resource-poor settings. The reliance of dengue virus on endogenous processes during the late stages of infection prompts the development of molecules to interfere with and exploit these dependencies as potential antiviral therapies. Here we focus on the importance of N-linked glycan processing in infectious virion morphogenesis.
登革热病毒作为一种重要的人类病原体再次出现，导致对有效抗病毒药物的需求不断增加。在登革热流行资源匮乏的环境中，开发能够减轻感染后患者疾病持续时间和严重程度的治疗药物是特别需要的。登革热病毒在感染后期依赖于内源性过程，这促使人们开发能够干扰和利用这些依赖性的分子作为潜在的抗病毒治疗方法。在这里，我们重点关注 N-连接糖基化加工在感染性病毒粒子形态发生中的重要性。
