School of Life Science, Institute of Cognitive Neuroscience, Key Laboratory of Brain Functional Genomics, Ministry of Education of China, East China Normal University, Shanghai, China.
Neurosci Lett. 2010 Jul 12;478(3):119-23. doi: 10.1016/j.neulet.2010.05.001. Epub 2010 May 7.
Development of auditory function can be affected by environment and experience. In this study, we investigated whether the NMDA receptor mediates the plasticity of auditory spatial representation during development of the rat auditory cortex. We found that early auditory experience significantly increased the auditory spatial sensitivity of A1 neurons and induced training-dependent plasticity. Implantation of Elvax-APV in the auditory cortex gradually reduced the auditory spatial sensitivity of A1 neurons and blocked the auditory spatial plasticity induced by early auditory experience. These results indicate that the NMDA receptor has a key role in experience-dependent plasticity of auditory cortical circuits immediately after birth.
听觉功能的发育会受到环境和经验的影响。在这项研究中，我们探究了 NMDA 受体是否在大鼠听觉皮层发育过程中介导了听觉空间表征的可塑性。我们发现，早期听觉经验显著提高了 A1 神经元的听觉空间敏感性，并诱导了训练依赖性的可塑性。在听觉皮层中植入 Elvax-APV 逐渐降低了 A1 神经元的听觉空间敏感性，并阻断了早期听觉经验诱导的听觉空间可塑性。这些结果表明，NMDA 受体在出生后立即的听觉皮层回路的经验依赖性可塑性中起关键作用。
