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长寿联盟:利用多种方法了解人类长寿和健康衰老的遗传基础。一系列文章介绍。

The Longevity Consortium: Harnessing diverse approaches to understand the genetic basis of human longevity and healthy aging. An introduction to a series of articles.

出版信息

Ageing Res Rev. 2011 Apr;10(2):179-80. doi: 10.1016/j.arr.2010.04.008. Epub 2010 May 7.

DOI:10.1016/j.arr.2010.04.008
PMID:20452463
Abstract

The Longevity Consortium is a multi-investigator, multi-institutional research group focused on identifying the genetic variants that regulate human lifespan and healthy aging. The text that follows is an introduction to a series of seven articles prepared by Consortium investigators that represent a profile of planned and ongoing research and up-to-date reviews of topics of major interest to biogerontologists and others scientists and clinicians interested in ageing research.

摘要

长寿联盟是一个多研究员、多机构的研究团队,专注于鉴定调节人类寿命和健康衰老的遗传变异。以下是联盟研究员撰写的七篇文章的简介,这些文章代表了计划中的和正在进行的研究概况,以及对生物老年学家和其他对衰老研究感兴趣的科学家和临床医生关注的主要课题的最新综述。

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1
The Longevity Consortium: Harnessing diverse approaches to understand the genetic basis of human longevity and healthy aging. An introduction to a series of articles.长寿联盟:利用多种方法了解人类长寿和健康衰老的遗传基础。一系列文章介绍。
Ageing Res Rev. 2011 Apr;10(2):179-80. doi: 10.1016/j.arr.2010.04.008. Epub 2010 May 7.
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Design and analysis in genetic studies of human ageing and longevity.人类衰老与长寿基因研究中的设计与分析
Ageing Res Rev. 2006 Nov;5(4):371-87. doi: 10.1016/j.arr.2005.10.002. Epub 2005 Dec 6.
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[On human ageing and longevity--2. Internal determinants].[论人类衰老与长寿——2. 内在决定因素]
Cas Lek Cesk. 2009;148(7):330-4.
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The molecular basis of longevity, and clinical implications.长寿的分子基础及临床意义。
Maturitas. 2010 Feb;65(2):87-91. doi: 10.1016/j.maturitas.2009.12.008. Epub 2010 Jan 6.
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GEHA--the pan-European "Genetics of Healthy Aging" project.GEHA——泛欧“健康衰老遗传学”项目。
Sci Aging Knowledge Environ. 2004 May 26;2004(21):pe23. doi: 10.1126/sageke.2004.21.pe23.
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Can we intervene in human ageing?我们能否干预人类衰老过程?
Expert Rev Mol Med. 2009 Sep 7;11:e27. doi: 10.1017/S1462399409001197.
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Genomic studies in ageing research: the need to integrate genetic and gene expression approaches.衰老研究中的基因组学研究:整合遗传和基因表达方法的必要性。
J Intern Med. 2008 Feb;263(2):153-66. doi: 10.1111/j.1365-2796.2007.01904.x.
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Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?区分因果关系:胰岛素/胰岛素样生长因子信号通路如何控制线虫、果蝇和小鼠的寿命?
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Biomarkers of aging and disease: introduction and definitions.衰老和疾病的生物标志物:引言和定义。
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Longevity and the stress response in Drosophila.果蝇的寿命与应激反应
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Centenarian studies: important contributors to our understanding of the aging process and longevity.
百岁老人研究:对我们理解衰老过程和长寿的重要贡献者。
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