Cardiac Surgery, Yale School of Medicine, PO Box 208039, New Haven, CT 06520-8039, USA.
Cardiol Clin. 2010 May;28(2):207-11. doi: 10.1016/j.ccl.2010.01.009.
Identification of biomarkers for thoracic aortic aneurysm (TAA) disease is important because complications of TAAs are common. Preemptive operative repair of TAAs is effective in improving survival. However, elective surgical repair for asymptomatic aneurysms remains a clinical decision that must be based on the patient's operative risk and the risk that a given TAA will rupture. Thus, it is vitally important to be able to identify which patients with TAAs are at the greatest risk for rupture or dissection. Markers in clinical use and potential markers at the cellular, protein, and molecular level are discussed.
鉴定胸主动脉瘤（TAA）疾病的生物标志物很重要，因为 TAA 的并发症很常见。预防性手术修复 TAA 可有效提高生存率。然而，对于无症状的动脉瘤，选择性手术修复仍然是一个临床决策，必须基于患者的手术风险和特定 TAA 破裂的风险。因此，能够识别哪些 TAA 患者的破裂或夹层风险最大至关重要。本文讨论了临床应用中的标志物和细胞、蛋白质和分子水平上的潜在标志物。
