Mok H, Mulpeter K, O'Connor P, Feely J
Department of Therapeutics, Trinity College Medical School, St. James's Hospital, Dublin.
Ir Med J. 1991 Mar;84(1):26.
Drug prescription charts of 200 randomly selected general medical patients in two Dublin hospitals were examined for potential drug-drug interactions. Using the Stockly Interaction alert, 37% of these patients had potential interactions but in only three was there clinical evidence that an interaction occurred. In an analysis of 150 spontaneous (yellow card) adverse drug reactions reports interactions contributed to only 8%. These results suggest that the importance of interactions as a cause of drug toxicity is commonly over-estimated.
对都柏林两家医院随机抽取的200名普通内科患者的药物处方进行了检查，以查找潜在的药物相互作用。使用斯托克利相互作用警示系统，这些患者中有37%存在潜在相互作用，但只有3例有临床证据表明发生了相互作用。在对150份自发（黄卡）药物不良反应报告的分析中，相互作用仅占8%。这些结果表明，人们通常高估了相互作用作为药物毒性原因的重要性。
