Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstrasse 10, Fach 720, 78457 Konstanz, Germany.
J Inorg Biochem. 2010 Aug;104(8):863-7. doi: 10.1016/j.jinorgbio.2010.04.003. Epub 2010 Apr 24.
Reaction of the known titanocene Y 2 with methyl lithium at -15 degrees C yields bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with the free carboxylic acids in fair to good yields. Cytotoxicity of all new compounds has been estimated in Hela S3 cells.
已知的二茂钛 Y2 与甲基锂在-15°C反应，生成双-[(对甲氧基苄基)环戊二烯基]钛(IV)二甲基金属（二甲基钛 Y，3），这是一种迄今未知的、令人惊讶的稳定钛(IV)二甲基金属物种。二甲基钛 Y 被用于通过与游离羧酸反应制备几种双-[(对甲氧基苄基)环戊二烯基]钛(IV)二羧酸酯，收率中等至良好。所有新化合物的细胞毒性都在 Hela S3 细胞中进行了评估。
