Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Trends Cell Biol. 2010 Jul;20(7):410-7. doi: 10.1016/j.tcb.2010.04.005. Epub 2010 May 7.
The Hippo signaling pathway is a key regulator of growth during animal development, whereas loss of normal Hippo pathway activity is associated with a wide range of cancers. Hippo signaling represses growth by inhibiting the activity of a transcriptional co-activator protein, known as Yorkie in Drosophila and Yap in vertebrates. In the 5 years since the first report linking Yorkie to Hippo signaling, intense interest in this pathway has led to rapid increases in our understanding of the action and regulation of Yorkie/Yap, which we review here. These studies have also emphasized the complexity of Yorkie/Yap regulation, including multiple, distinct mechanisms for repressing its transcriptional activity, and multiple DNA-binding partner proteins that can direct Yorkie to distinct downstream target genes.
Hippo 信号通路是动物发育过程中生长的关键调节剂，而正常 Hippo 通路活性的丧失与广泛的癌症有关。Hippo 信号通过抑制转录共激活蛋白的活性来抑制生长，该蛋白在果蝇中称为 Yorkie，在脊椎动物中称为 Yap。自第一篇将 Yorkie 与 Hippo 信号联系起来的报告发表以来的 5 年中，人们对该通路的浓厚兴趣导致我们对 Yorkie/Yap 的作用和调节的理解迅速增加，我们在此对其进行综述。这些研究还强调了 Yorkie/Yap 调节的复杂性，包括多种不同的机制来抑制其转录活性，以及多种 DNA 结合伙伴蛋白，可以将 Yorkie 引导到不同的下游靶基因。
