肌动蛋白的核功能。
Nuclear functions of actin.
机构信息
Department of Molecular Biology & Functional Genomics, Stockholm University, Sweden.
出版信息
Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a000620. doi: 10.1101/cshperspect.a000620. Epub 2010 Mar 17.
Abstract
Actin participates in several essential processes in the cell nucleus. Even though the presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes that require actin have been only recently identified. Actin is part of chromatin remodeling complexes; it is associated with the transcription machineries; it becomes incorporated into newly synthesized ribonucleoproteins; and it influences long-range chromatin organization. As in the cytoplasm, nuclear actin works in conjunction with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and other nuclear components.
摘要
肌动蛋白参与细胞核中的几个基本过程。尽管肌动蛋白存在于细胞核中这一观点早在 30 多年前就已提出，但直到最近才发现需要肌动蛋白参与的核过程。肌动蛋白是染色质重塑复合物的一部分；它与转录机制相关联；它被整合到新合成的核糖核蛋白中；并影响长距离染色质组织。与细胞质中一样，核肌动蛋白与不同类型的肌动蛋白结合蛋白协同作用，这些蛋白调节肌动蛋白的功能，并在肌动蛋白与其他核成分之间架起桥梁。
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