Roels Stefan, Coopman Vera, Vanhaelen Pascal, Cordonnier Jan
Veterinary and Agrochemical Research Centre (CODA/CERVA), Operational Direction of Interactions and Surveillance, Unit of Pathology, Groeselenberg 99, 1180 Brussels (Ukkel), Belgium.
J Vet Diagn Invest. 2010 May;22(3):466-8. doi: 10.1177/104063871002200325.
Two adult dogs with the same owner were intoxicated by ingestion of fertilizer composed of residual plant material of the castor bean plant (Ricinus communis L.). Both dogs died within 2 and 3 days, respectively, after the first signs of vomiting and abundant hemorrhagic diarrhea. Toxicologic and histopathologic examinations were performed on different organs. Histopathologic examination of the kidneys revealed tubular degeneration and necrosis and membranous glomerulonephritis. Additionally, myocardial degeneration with localized inflammation, lymphoid necrosis, and depletion in the spleen and mesenteric lymph nodes and hemorrhagic ulcerative gastroenteritis were found. The 2 cases could be used to elucidate the lethal dose of ricin and the histopathologic lesions in dogs.
两只由同一主人饲养的成年犬因摄入由蓖麻植物（Ricinus communis L.）残余植物材料组成的肥料而中毒。在出现呕吐和大量出血性腹泻的最初症状后，两只狗分别在2天和3天内死亡。对不同器官进行了毒理学和组织病理学检查。肾脏的组织病理学检查显示肾小管变性和坏死以及膜性肾小球肾炎。此外，还发现心肌变性伴局部炎症、脾脏和肠系膜淋巴结中的淋巴细胞坏死和耗竭以及出血性溃疡性肠胃炎。这2例病例可用于阐明蓖麻毒素对犬的致死剂量和组织病理学损伤。
