Jakobsen J
Diabetologia. 1978 Feb;14(2):113-9. doi: 10.1007/BF01263449.
The aim of the present study was to examine whether the nerve water content and the Schwann cell cytoplasm are increased in early experimental diabetics, as suggested in the sorbitol theory. The sciatic nerves of streptozotocin diabetic rats were found to have an increased wet weight. The amount of Schwann cell cytoplasm was reduced by 30%. The increased wet weight was paralleled by enlargement of the cross sectional area of the nerve which was explained by an expansion of the endoneurial space. The findings indicate the existence of endoneurial oedema and are in part in conflict with the sorbitol theory. Extension of the space surrounding the nerve fibres may explain the increased resistance to ischaemia in diabetic patients.
本研究的目的是检验在早期实验性糖尿病中，如在山梨醇理论中所提出的，神经含水量和施万细胞胞质是否增加。链脲佐菌素诱导的糖尿病大鼠的坐骨神经湿重增加。施万细胞胞质的量减少了30%。湿重增加的同时神经横截面积增大，这可由神经内膜间隙扩张来解释。这些发现表明存在神经内膜水肿，部分与山梨醇理论相矛盾。神经纤维周围间隙的扩大可能解释了糖尿病患者对缺血的耐受性增加。
