Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Via dell'Angelo 1, Benevento, Italy.
Dermatology. 2010;220(4):306-10. doi: 10.1159/000300093. Epub 2010 May 6.
The diagnosis of pediatric atypical Spitz nevus/tumors (pASNT) is an emerging challenge in clinical dermatology and dermatopathology.
We review the main clinicopathologic issues raised by pASNT and describe 2 examples of different clinicopathologic subsets of lesions.
While Spitz/Reed nevi are commonly small- to medium-sized, tan to black plaques, pASNT are large and nodular, either 'red' (dotted and/or polymorphous vascular pattern on dermoscopy; spindle and/or epithelioid tumors on histopathology: Spitz tumors, sensu strictiori) or 'blue' (homogeneous blue color on dermoscopy; intimate admixture of epithelioid cells and heavily pigmented dendritic cells on histopathology: Blitz tumors or pigmented epithelioid melanocytomas).
Different clinicopathologic settings of pASNT probably exist. Dermoscopy can aid in their recognition and classification.
儿科非典型 Spitz 痣/肿瘤（pASNT）的诊断是临床皮肤科和皮肤病理学领域面临的新挑战。
我们回顾了 pASNT 提出的主要临床病理问题，并描述了两种不同临床病理亚组病变的实例。
Spitz/Reed 痣通常为小至中等大小，呈棕黑色斑块，而 pASNT 则较大且呈结节状，呈“红色”（皮损镜检呈点状和/或多形性血管模式；组织病理学呈梭形和/或上皮样肿瘤：严格意义上的 Spitz 肿瘤）或“蓝色”（皮损镜检呈均匀蓝色；组织病理学呈上皮样细胞和重度色素性树突状细胞混合：Blitz 肿瘤或色素性上皮样黑素细胞瘤）。
pASNT 可能存在不同的临床病理表现。皮损镜检有助于识别和分类。
