Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
Am J Nephrol. 2010;31(6):510-7. doi: 10.1159/000309789. Epub 2010 May 7.
BACKGROUND/AIMS: Fetuin-A is a negative acute-phase reactant and extraosseous calcification inhibitor. Decreased serum concentration of fetuin-A is independently related to all-cause and cardiovascular mortality in dialysis patients. Our aim is to investigate the association between the genetic polymorphism of alpha(2)-Heremans-Schmid-glycoprotein (AHSG) encoding fetuin-A and its serum concentration, vascular calcification, and aortic stiffness in peritoneal dialysis (PD) patients.
A total of six single nucleotide polymorphisms (SNPs) in the AHSG gene were genotyped and evaluated for association with serum fetuin-A level, quantitative measures of vascular calcification and aortic stiffness represented by heart-to-femoral pulse wave velocity (hfPWV).
Five SNPs in the AHSG gene were nominally associated with the serum fetuin-A level in our PD patients. In haplotype analyses, there were haplotypes positively (H1; AGCA, H2; CC) and inversely (H1; TTCG, H2; TT) related with the serum fetuin-A level. The serum fetuin-A level inversely and independently correlated with hfPWV. Moreover, the serum fetuin-A concentration was a determinant for the simple vascular calcification score (SVCS), which subsequently was associated with hfPWV.
Our study showed an association between AHSG polymorphism and its serum concentration, and also revealed an association of the serum fetuin-A level with SVCS and aortic stiffness in PD patients.
背景/目的：胎球蛋白-A 是一种负急性时相反应物和骨外钙化抑制剂。血清胎球蛋白-A 浓度降低与透析患者的全因和心血管死亡率独立相关。我们的目的是研究编码胎球蛋白-A 的 α(2)-赫曼斯-施密特糖蛋白（AHSG）的基因多态性与胎球蛋白-A 血清浓度、血管钙化和腹膜透析（PD）患者的主动脉僵硬之间的关系。
对 AHSG 基因中的 6 个单核苷酸多态性（SNP）进行基因分型，并评估其与血清胎球蛋白-A 水平、血管钙化和主动脉僵硬的定量指标（以心-股脉搏波速度（hfPWV）表示）之间的关联。
在我们的 PD 患者中，AHSG 基因中的 5 个 SNP 与血清胎球蛋白-A 水平呈显著相关。在单倍型分析中，存在与血清胎球蛋白-A 水平呈正相关的单倍型（H1；AGCA，H2；CC）和负相关的单倍型（H1；TTCG，H2；TT）。血清胎球蛋白-A 水平与 hfPWV 呈负相关且独立相关。此外，血清胎球蛋白-A 浓度是简单血管钙化评分（SVCS）的决定因素，随后与 hfPWV 相关。
我们的研究表明 AHSG 多态性与其血清浓度之间存在关联，并且还揭示了 PD 患者血清胎球蛋白-A 水平与 SVCS 和主动脉僵硬之间的关联。
