Fonds de la Recherche Scientifique (FNRS), Laboratoire de Psychologie Médicale, Université Libre de Bruxelles, Belgium.
Int Clin Psychopharmacol. 2010 Jul;25(4):228-31. doi: 10.1097/YIC.0b013e328338bcf4.
The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.
5HT2A（5HTR2A）和 5HT1A 受体（5HTR1A）基因是重度抑郁症的合理候选基因。在 206 名符合《精神障碍诊断与统计手册》第四版重度抑郁症标准的患者中，分析了 5HTR2A 的 rs7997012 和 5HTR1A 的-1019C/G 这两个单核苷酸多态性。对患者的抗抑郁治疗反应进行了回顾性特征分析。我们发现，在 rs7997012 等位基因频率上，耐药和非耐药患者之间存在显著差异。然而，经过 Bonferroni 校正后，我们没有发现这个单核苷酸多态性与治疗抵抗表型之间存在任何关联。尽管如此，由于我们分析的能力有限，我们不能得出这些结果反映出缺乏关联的结论。需要开展更多的研究来证实或反驳我们的结果。
