Division of Cardiology, University of British Columbia and British Columbia Children's Hospital, Vancouver, BC, Canada.
Pediatr Crit Care Med. 2011 Jan;12(1):e43-5. doi: 10.1097/PCC.0b013e3181e2a388.
To report a case of postnatal, postoperative amiodarone-induced hypothyroidism in an infant with a congenital heart defect.
Case report and literature review.
Pediatric intensive care unit at a freestanding tertiary care children's hospital.
At 7 wks of age, a female infant with a congenital heart defect was confirmed to have profound hypothyroidism after amiodarone administration for a postoperative cardiac arrhythmia.
Levothyroxine treatment.
Thyroid function tests were regularly performed to guide levothyroxine dosing. Thyroid hormone replacement was discontinued after the infant had been off amiodarone for 6 mos.
Given the potential adverse developmental consequences associated with hypothyroidism during infancy and early childhood, thyroid function tests should be carefully monitored in any infant treated with amiodarone.
报告一例先天性心脏病婴儿在术后使用胺碘酮后出现的甲状腺功能减退症。
病例报告和文献复习。
一家独立的三级儿童保健医院的儿科重症监护病房。
一名患有先天性心脏病的女性婴儿，在因心律失常接受胺碘酮治疗后，于 7 周龄时被确诊为严重甲状腺功能减退症。
左甲状腺素治疗。
定期进行甲状腺功能检查以指导左甲状腺素的剂量。在婴儿停用胺碘酮 6 个月后，停止甲状腺激素替代治疗。
鉴于甲状腺功能减退症在婴儿和幼儿期可能导致的不良发育后果，在使用胺碘酮治疗的任何婴儿中，均应仔细监测甲状腺功能检查。
