Hotchkiss Brain Institute, Department of Cell Biology & Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada.
Nat Neurosci. 2010 Jun;13(6):753-8. doi: 10.1038/nn.2550. Epub 2010 May 9.
In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition behavior and associated brain plasticity has been well characterized, but paternal recognition behavior and brain plasticity is poorly understood. We found that paternal-adult offspring recognition behavior in mice was dependent on postnatal offspring interaction and was associated with increased neurogenesis in the paternal olfactory bulb and hippocampus. Newly generated paternal olfactory interneurons were preferentially activated by adult offspring odors. Disrupting prolactin signaling abolished increased paternal neurogenesis and adult offspring recognition. Rescuing this neurogenesis restored recognition behavior. Thus, neurogenesis in the paternal brain may be involved in offspring recognition.
在哺乳动物中，嗅觉通常用于根据个体独特的气味类型（遗传编程的体气味）来区分个体。亲代-后代识别行为部分受不同气味类型的学习和处理介导，对繁殖成功至关重要。母体识别行为及其相关的大脑可塑性已经得到很好的描述，但父体识别行为和大脑可塑性知之甚少。我们发现，小鼠的父体-成年后代识别行为依赖于产后后代的相互作用，并与父体嗅球和海马体中的神经发生增加有关。新生的父体嗅觉中间神经元优先被成年后代的气味激活。破坏催乳素信号会消除父体神经发生和成年后代的识别增加。挽救这种神经发生恢复了识别行为。因此，父体大脑中的神经发生可能参与了后代识别。
