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皮质对腹侧脑室下区神经发生和细胞增殖的调节。

Cortical regulation of neurogenesis and cell proliferation in the ventral subventricular zone.

机构信息

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.

Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.

出版信息

Cell Rep. 2023 Jul 25;42(7):112783. doi: 10.1016/j.celrep.2023.112783. Epub 2023 Jul 8.

DOI:10.1016/j.celrep.2023.112783
PMID:37422764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10422956/
Abstract

Neurogenesis and differentiation of neural stem cells (NSCs) are controlled by cell-intrinsic molecular pathways that interact with extrinsic signaling cues. In this study, we identify a circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone (LV-SVZ). Our results demonstrate that direct glutamatergic projections from the anterior cingulate cortex (ACC), as well as inhibitory projections from calretinin local interneurons, modulate the activity of cholinergic neurons in the subependymal zone (subep-ChAT). Furthermore, in vivo optogenetic stimulation and inhibition of the ACC-subep-ChAT circuit are sufficient to control neurogenesis in the ventral SVZ. Both subep-ChAT and local calretinin neurons play critical roles in regulating ventral SVZ neurogenesis and LV-SVZ cell proliferation.

摘要

神经发生和神经干细胞（NSCs）的分化受细胞内分子途径的控制，这些途径与外在信号线索相互作用。在这项研究中，我们确定了一个调节侧脑室-室下区（LV-SVZ）神经发生和细胞增殖的回路。我们的结果表明，来自前扣带皮层（ACC）的直接谷氨酸能投射，以及来自钙视网膜蛋白局部中间神经元的抑制性投射，调节了室下区（subep-ChAT）胆碱能神经元的活性。此外，体内光遗传学刺激和抑制 ACC-subep-ChAT 回路足以控制腹侧 SVZ 的神经发生。subep-ChAT 和局部钙视网膜蛋白神经元在调节腹侧 SVZ 神经发生和 LV-SVZ 细胞增殖方面都起着关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/1023eda9c44b/nihms-1920509-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/a597f7780f1c/nihms-1920509-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/b22fee50d265/nihms-1920509-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/fd2329379b47/nihms-1920509-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/4c5124134b2c/nihms-1920509-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/8521a838c3e1/nihms-1920509-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/5802ee87f231/nihms-1920509-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/1023eda9c44b/nihms-1920509-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/a597f7780f1c/nihms-1920509-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/b22fee50d265/nihms-1920509-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/fd2329379b47/nihms-1920509-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/4c5124134b2c/nihms-1920509-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/8521a838c3e1/nihms-1920509-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/5802ee87f231/nihms-1920509-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/10422956/1023eda9c44b/nihms-1920509-f0008.jpg

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J Neurochem. 2021 Feb;156(4):465-480. doi: 10.1111/jnc.14984. Epub 2020 Mar 12.
2
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain.神经干细胞：成年哺乳动物大脑中的起源、异质性和调控。
Development. 2019 Feb 18;146(4):dev156059. doi: 10.1242/dev.156059.
3
Neural Regen Res. 2025 Jun 1;20(6):1565-1581. doi: 10.4103/NRR.NRR-D-24-00312. Epub 2024 Jun 26.
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation.
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Cell Stem Cell. 2018 Feb 1;22(2):221-234.e8. doi: 10.1016/j.stem.2018.01.003.
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The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.成人心室下区（V-SVZ）与嗅球（OB）神经发生
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