Matthes P, Kruegel J, Karapantzou C, Winterhoff J, Laskawi R
Klinik für Hals-Nasen-Ohren-Heilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
HNO. 2010 May;58(5):452-8. doi: 10.1007/s00106-009-2056-3.
There are no regional data about the prevalence and use of botulinum toxin (BoNT) in otorhinolaryngology (ORL) departments in Germany. In order to obtain an overview of the current applications of BoNT in ORL departments a survey was carried out.
Standardized multi-choice questionnaires were mailed to 150 ORL departments. In the analysis a differentiation was made between university and regional departments. Also an analysis of the whole collective of respondent hospitals was carried out. The most commonly treated indication is the Frey syndrome followed by hypersalivation due to a salivary fistula after parotidectomy, dysphagia, aesthetic application and laryngeal dystonia.
The rate of return was 62% and 75% of all responding hospitals use BoNT as a therapeutic option, especially where "off-label-use" indications are concerned (15 out of 20 indications or 75%).
BoNT is widely used as a therapeutic option with an increasing trend. Due to different applications a schedule of hospitals would be helpful in order to be able to find the nearest hospital for the appropriate indications.
德国尚无关于耳鼻喉科（ORL）肉毒杆菌毒素（BoNT）患病率及使用情况的区域数据。为了全面了解BoNT在耳鼻喉科的当前应用情况，开展了一项调查。
向150个耳鼻喉科科室邮寄了标准化的多项选择题问卷。分析时区分了大学科室和地区科室。同时对所有受访医院进行了整体分析。最常见的治疗适应症是 Frey 综合征，其次是腮腺切除术后涎瘘导致的流涎过多、吞咽困难、美容应用和喉肌张力障碍。
回复率为62%，75%的受访医院将BoNT用作治疗选择，尤其是在涉及“未按药品说明书用药”适应症的情况下（20种适应症中的15种，即75%）。
BoNT作为一种治疗选择被广泛使用，且呈上升趋势。由于应用情况各异，制定一份医院名录将有助于为合适的适应症找到最近的医院。
