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[耳鼻喉科医学中的肉毒杆菌毒素]

[Botulinum toxin in ENT medicine].

作者信息

Rohrbach S, Laskawi R

机构信息

HNO-Klinik der Universität Göttingen.

出版信息

Laryngorhinootologie. 2003 Mar;82(3):202-13; quiz 214-8. doi: 10.1055/s-2003-38407.

Abstract

In otorhinolaryngology, botulinum toxin is a suitable therapeutic option in the muscular and the autonomic nervous system concerning dysfunctions. Respecting some special aspects, it is an effective treatment for disorders of different etiology with very few side-effects. The positive therapeutic effect is temporarily limited, so that the patients need further treatment. Beside the classical indications like the facial hyperkinesias (i.e. blepharospasms, hemifacial spasm) the treatment of complex dystonias (oromandibular dystonia, laryngeal dystonia, cervical dystonia), gustatory sweating, hypersalivation and crocodile tears is successful. Botulinum toxin is an alternative treatment of tension type headache and migraine. A new indication of botulinum toxin application may lay in the treatment of nasal hypersecretion through the effect on the nasal glands.

摘要

在耳鼻咽喉科,肉毒杆菌毒素是治疗肌肉和自主神经系统功能障碍的一种合适选择。考虑到一些特殊方面,它是治疗不同病因疾病的有效方法,且副作用极少。其积极的治疗效果是暂时的,因此患者需要进一步治疗。除了面部运动亢进(如眼睑痉挛、面肌痉挛)等经典适应症外,肉毒杆菌毒素治疗复杂性肌张力障碍(口下颌肌张力障碍、喉肌张力障碍、颈部肌张力障碍)、味觉性出汗、唾液分泌过多和鳄鱼泪也取得了成功。肉毒杆菌毒素是紧张型头痛和偏头痛的替代治疗方法。肉毒杆菌毒素应用的一个新适应症可能在于通过对鼻腺的作用来治疗鼻分泌物过多。

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