Department of Urology, Faculty of Medicine in Pilsen, Charles University in Prague and Faculty Hospital, Dr. E. Benese 13, 30599, Plzen, Czech Republic.
World J Urol. 2010 Aug;28(4):513-7. doi: 10.1007/s00345-010-0563-1. Epub 2010 May 8.
Types 1 and 2 by Delahunt of papillary renal cell carcinoma (PRCC) are traditionally differentiated. An oncocytic variant of PRCC (O-PRCC) has recently been described. We compare clinical data of O-PRCC with other subtypes of PRCC such as the main tumour size, necrotic changes, presence of pseudocapsula and real extrarenal growth in retrospective study.
From 1/1992 to 10/2009, 1,398 patients with 1,436 renal tumours were surgically treated in our institution. PRCCs were described in 109 (7.6%). Among PRCC, O-PRCCs were in 12 (11%), PRCC type 1 in 86 (78.9%), PRCC type 2 in 8 (7.3%) and others in 3 (2.8%) cases.
The patient's mean age with O-PRCC (M:F ratio = 2:1) was 67.5 +/- 10.9 versus 63.5 +/- 14.1 in type 1 and 57.9 +/- 5.7 in type 2, the mean tumour size was 35 +/- 12 mm versus 47 +/- 22 and 37 +/- 17, respectively. The follow-up of O-PRCC is 35.3 +/- 12.3 months and all cases are without recurrence. We did not find any pseudocapsula in O-PRCC but it was a major sign of PRCC type 1 (32.6%). Huge microscopic necrotic changes were described in 33.3% of O-PRCC, in 33.7% of PRCC type 1 and 62.5% of PRCC type 2. Extrarenal growth was found only in 16.7% O-PRCC versus 40.7% in PRCC type I.
None of the O-PRCC had pseudocapsula and none had massive necroses in comparison of O-PRCC with PRCC types I and II. Extrarenal growth in O-PRCC is relatively rare. The malignant potential of O-PRCC is low.
传统上将 1 型和 2 型 Delahunt 乳头状肾细胞癌 (PRCC) 进行区分。最近描述了 PRCC 的一种嗜酸细胞变体 (O-PRCC)。我们在回顾性研究中比较了 O-PRCC 与其他 PRCC 亚型（如主要肿瘤大小、坏死变化、假包膜存在和真正的肾外生长）的临床数据。
1992 年 1 月至 2009 年 10 月，我们机构对 1398 例 1436 例肾肿瘤患者进行了手术治疗。在 109 例 (7.6%) 中描述了 PRCC。在 PRCC 中，O-PRCC 为 12 例 (11%)，PRCC 1 型为 86 例 (78.9%)，PRCC 2 型为 8 例 (7.3%)，其他类型为 3 例 (2.8%)。
O-PRCC 患者的平均年龄（男女比例为 2:1）为 67.5 +/- 10.9 岁，1 型为 63.5 +/- 14.1 岁，2 型为 57.9 +/- 5.7 岁，平均肿瘤大小为 35 +/- 12 毫米，分别为 47 +/- 22 和 37 +/- 17。O-PRCC 的随访时间为 35.3 +/- 12.3 个月，所有病例均无复发。我们在 O-PRCC 中未发现任何假包膜，但它是 PRCC 1 型的主要标志（32.6%）。33.3%的 O-PRCC 有巨大的显微镜下坏死变化，33.7%的 PRCC 1 型和 62.5%的 PRCC 2 型有巨大的坏死变化。仅在 16.7%的 O-PRCC 中发现肾外生长，而在 PRCC 1 型中为 40.7%。
与 PRCC 1 型和 2 型相比，O-PRCC 中没有假包膜，也没有大量坏死。O-PRCC 的肾外生长相对较少。O-PRCC 的恶性潜能较低。
