Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-dong, Jongro-Gu, Seoul, Korea.
J Neural Transm (Vienna). 2010 Jun;117(6):773-9. doi: 10.1007/s00702-010-0412-9. Epub 2010 May 9.
The purpose of this study was to examine the relationship between the C(-1019)G polymorphism of the serotonin-1A receptor gene and eating behavior in female adolescents. A total of 204 post-menarche, adolescent women, aged 16-17 years, were recruited from two neighboring high schools in Seoul. Polymerase chain reaction (PCR) was used to isolate and examine the C(-1019)G polymorphism in the serotonin-1A receptor genes (rs6295) of all participants. The Bulimia Investigatory Test, Edinburgh (BITE) and the Eating Attitude Test-26 (EAT-26) were administered to all participants. The total score of the EAT-26 differed significantly among the three genotype groups [CC, CG, GG (F = 4.844, p = 0.009)]. Both the EAT-26 (F = 9.69, p = 0.002) and the BITE (F = 5.22, p = 0.023) scores were higher in the participants who were G allele carriers than in the non-carrier group. The dieting subscale of the EAT-26 was higher among the G allele carriers (F = 12.941, p < 0.001), and these results were maintained even after adjusting for depression and anxiety. These findings suggest that the C(-1019)G polymorphism in the 5-HT1A receptor gene is associated with disordered eating symptoms in Korean female adolescents.
本研究旨在探讨 5-羟色胺 1A 受体基因 C(-1019)G 多态性与女性青少年进食行为之间的关系。从首尔的两所相邻高中招募了 204 名初潮后、年龄在 16-17 岁的青春期女性。使用聚合酶链反应（PCR）分离并检测所有参与者的 5-羟色胺 1A 受体基因（rs6295）中的 C(-1019)G 多态性。所有参与者均接受了暴食症调查测试-爱丁堡（BITE）和饮食态度测试-26（EAT-26）的评估。EAT-26 的总分在三个基因型组[CC、CG、GG（F=4.844，p=0.009）]之间存在显著差异。EAT-26（F=9.69，p=0.002）和 BITE（F=5.22，p=0.023）的得分在 G 等位基因携带者中均高于非携带者组。EAT-26 的节食亚量表在 G 等位基因携带者中更高（F=12.941，p<0.001），即使在调整抑郁和焦虑后，这些结果仍然存在。这些发现表明，5-HT1A 受体基因中的 C(-1019)G 多态性与韩国女性青少年的饮食失调症状有关。
