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5-羟色胺1A受体基因C-1019G(rs6295)多态性的C/C基因型与墨西哥农村人群中抑郁症状较低易感性相关。

The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico.

作者信息

Hernandez-Mixteco Margarita, Valenzuela Olga Lidia, Balderas-Vazquez Cecilia Luz, Castillo-Juárez Paola, Rivera-Gutiérrez Sandra, García-Reyes Rocío Liliana, Cornejo-Estudillo Gilberto, Soria-Herrera Ricardo Jiovanni, León-Juárez Moises, Helguera-Repetto Addy Cecilia, Valencia-Trujillo Daniel, Campos-Peña Victoria, Garcia-Montalvo Eliud Alfredo, Cerna-Cortés Jorge Francisco

机构信息

Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.

Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz 94340, Mexico.

出版信息

Neurol Int. 2025 May 31;17(6):87. doi: 10.3390/neurolint17060087.

Abstract

BACKGROUND

Depression is one of the most prevalent mental health disorders worldwide, affecting a significant proportion of the global population. Its etiology is complex and influenced by the interaction of environmental factors and genetic variations. In Mexico, it has been reported that 41.3% of the population exhibits depressive symptoms. Previous studies have suggested that susceptibility to depression may be associated with the C-1019G (rs6295) polymorphism in the serotonin 1A (5-HT1A) receptor gene.

OBJECTIVE

In this study, we aimed to evaluate the association between the C-1019G polymorphism and depressive symptoms in a rural Mexican population.

METHODS

Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), we examined the effect of C-1019G on depression symptoms, as evaluated by the Beck Depression Inventory. Data were obtained from 83 volunteers; individuals with depressive symptoms and those with a healthy mood were compared.

RESULTS

The results showed that the homozygous C/C genotype was found significantly more frequently in the control group than in individuals with depressive symptoms, particularly among men, and is thus associated with a decreased risk of depressive symptomatology.

CONCLUSIONS

The C/C genotype could protect against susceptibility to developing depressive symptoms in a rural population in Mexico.

摘要

背景

抑郁症是全球最常见的心理健康障碍之一,影响着很大一部分全球人口。其病因复杂,受环境因素和基因变异相互作用的影响。在墨西哥,据报道41.3%的人口表现出抑郁症状。先前的研究表明,抑郁症易感性可能与血清素1A(5-HT1A)受体基因中的C-1019G(rs6295)多态性有关。

目的

在本研究中,我们旨在评估墨西哥农村人口中C-1019G多态性与抑郁症状之间的关联。

方法

使用聚合酶链反应-限制性片段长度多态性(PCR-RFLP),我们通过贝克抑郁量表评估了C-1019G对抑郁症状的影响。数据来自83名志愿者;比较了有抑郁症状的个体和情绪健康的个体。

结果

结果显示,纯合子C/C基因型在对照组中出现的频率明显高于有抑郁症状的个体,尤其是在男性中,因此与抑郁症状的风险降低有关。

结论

C/C基因型可能对墨西哥农村人口患抑郁症状的易感性具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8d8/12196349/2c9b1b57af56/neurolint-17-00087-g001.jpg

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