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蜗牛家族调控与乳腺癌进展中的上皮间质转化。

Snail family regulation and epithelial mesenchymal transitions in breast cancer progression.

机构信息

IMIM-Hospital del Mar, Parc de Recerca Biomèdica de Barcelona, C/Doctor Aiguader, 88, 08003 Barcelona, Spain.

出版信息

J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):135-47. doi: 10.1007/s10911-010-9179-8. Epub 2010 May 9.

DOI:10.1007/s10911-010-9179-8
PMID:20455012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2930904/
Abstract

Since its initial description, the interconversion between epithelial and mesenchymal cells (designed as epithelial-mesenchymal or mesenchymal-epithelial transition, EMT or MET, respectively) has received special attention since it provides epithelial cells with migratory features. Different studies using cell lines have identified cytokines, intercellular signaling elements and transcriptional factors capable of regulating this process. Particularly, the identification of Snail family members as key effectors of EMT has opened new ways for the study of this cellular process. In this article we discuss the molecular pathways that control EMT, showing a very tight and interdependent regulation. We also analyze the contribution of EMT and Snail genes in the process of tumorigenesis using the mammary gland as cellular model.

摘要

自最初描述以来，上皮细胞和间充质细胞之间的相互转换（分别设计为上皮-间充质或间充质-上皮转化，EMT 或 MET）引起了特别关注，因为它赋予上皮细胞迁移特征。使用细胞系进行的不同研究已经鉴定出能够调节此过程的细胞因子、细胞间信号转导元件和转录因子。特别地，Snail 家族成员作为 EMT 的关键效应物的鉴定为研究这种细胞过程开辟了新的途径。在本文中，我们讨论了控制 EMT 的分子途径，显示出非常紧密和相互依赖的调节。我们还使用乳腺作为细胞模型分析 EMT 和 Snail 基因在肿瘤发生过程中的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/86d17b72adc3/halms485746f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/14393e4d3872/halms485746f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/42c4ba8d0ae6/halms485746f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/86d17b72adc3/halms485746f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/14393e4d3872/halms485746f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/42c4ba8d0ae6/halms485746f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4939/2930904/86d17b72adc3/halms485746f3.jpg

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