Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Arch Dermatol Res. 2010 Sep;302(7):507-15. doi: 10.1007/s00403-010-1052-5. Epub 2010 May 9.
Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABA(A) receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy control skin, using an immunohistochemistry technique. Pruritus was determined using a visual analog scale. Inflammatory cells immunoreactive for the GABA ligand and the GABA(A) R were increased (P < 0.01, respectively) in the involved skin. Cells stained for GABA ligand were mostly macrophages with some lymphocytes, while cells stained for GABA(A) R were macrophages, neutrophils or lymphocytes. There was a positive correlation when comparing GABA ligand (P = 0.05) and GABA(A) R (P < 0.05) expressing inflammatory cells, with pruritus. The GABA ligand and its GABA(A) R may play a role for the pathogenesis of psoriasis as well as for pruritus in this disease.
银屑病是一种慢性炎症性疾病，瘙痒是其常见症状。瘙痒可能与γ-氨基丁酸（GABA）系统有关。本研究采用免疫组织化学技术，研究了γ-氨基丁酸及其 GABA(A)受体（R）在受累和未受累银屑病皮肤以及正常健康对照皮肤中的分布。采用视觉模拟评分法评估瘙痒程度。在受累皮肤中，GABA 配体和 GABA(A)R 的免疫反应性细胞增加（分别为 P<0.01）。GABA 配体染色的细胞主要是巨噬细胞，伴有一些淋巴细胞，而 GABA(A)R 染色的细胞为巨噬细胞、中性粒细胞或淋巴细胞。比较 GABA 配体（P=0.05）和 GABA(A)R（P<0.05）表达的炎性细胞与瘙痒之间存在正相关。GABA 配体及其 GABA(A)R 可能在银屑病的发病机制以及该疾病的瘙痒中发挥作用。
