Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Handb Exp Pharmacol. 2004(165):343-72. doi: 10.1007/978-3-540-68170-0_11.
Nectins are Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecules which constitute a family of four members. Nectins homophilically and heterophilically trans-interact and cause cell-cell adhesion. This nectin-based cell-cell adhesion plays roles in the organization of adherens junctions in epithelial cells and fibroblasts and synaptic junctions in neurons in cooperation with cadherins. The nectin-based cell-cell adhesion plays roles in the contacts between commissural axons and floor plate cells and in the organization of Sertoli cell-spermatid junctions in the testis, independently of cadherins. Nectins furthermore regulate intracellular signaling through Cdc42 and Rac small G proteins and cell polarization through cell polarity proteins. Pathologically, nectins serve as entry and cell-cell spread mediators of herpes simplex viruses.
NECTIN 是一类不依赖钙离子的免疫球蛋白样细胞间黏附分子，由四个成员组成一个家族。NECTIN 可通过同嗜性和异嗜性反式相互作用，引起细胞间黏附。这种基于 NECTIN 的细胞间黏附与钙黏蛋白协同作用，在上皮细胞和成纤维细胞的黏着连接组织以及神经元的突触连接组织中发挥作用。基于 NECTIN 的细胞间黏附在连合轴突与底板细胞之间的接触以及睾丸中支持细胞 - 精子细胞连接的组织形成中发挥作用，且不依赖于钙黏蛋白。此外，NECTIN 通过 Cdc42 和 Rac 小 G 蛋白调节细胞内信号传导，并通过细胞极性蛋白调节细胞极化。在病理情况下，NECTIN 作为单纯疱疹病毒的进入和细胞间传播介质。
