Fujimura A, Ohashi K, Ebihara A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
J Clin Pharmacol. 1991 Jan;31(1):54-7. doi: 10.1002/j.1552-4604.1991.tb01886.x.
Circadian influence of trichlormethiazide on serum electrolyte levels, lipid levels, and glucose levels were evaluated in 12 hypertensive patients. One tablet of trichlormethiazide (2 mg) was given once a day at 7:00 AM or 7:00 PM for 8 weeks. The study was done by a crossover design. Twenty-four-hour urine was collected, and fasting blood samples were obtained during the control period and at the end of each treatment period. The 24-hour urine level increased slightly after treatment with trichlormethiazide in the morning and evening trials. Urinary excretion of sodium also increased slightly in the morning trial and increased significantly in the evening trial. Serum concentrations of potassium and chloride decreased, and serum uric acid level increased after trichlor-methiazide treatment. No significant difference was observed in these parameters between morning and evening trials. Fasting blood glucose levels increased after trichlormethiazide treatment. The increment in blood glucose levels was greater in the evening trial than in the morning trial. These data indicate that the influence of trichlormethiazide on glucose tolerance might vary with its administration time.
在12例高血压患者中评估了三氯噻嗪对血清电解质水平、血脂水平和血糖水平的昼夜影响。每天上午7:00或晚上7:00服用一片三氯噻嗪（2mg），持续8周。该研究采用交叉设计。收集24小时尿液，并在对照期和每个治疗期结束时采集空腹血样。在早晨和晚上的试验中，三氯噻嗪治疗后24小时尿量略有增加。早晨试验中尿钠排泄也略有增加，晚上试验中显著增加。三氯噻嗪治疗后血清钾和氯浓度降低，血清尿酸水平升高。早晨和晚上试验在这些参数上未观察到显著差异。三氯噻嗪治疗后空腹血糖水平升高。晚上试验中血糖水平的升高幅度大于早晨试验。这些数据表明，三氯噻嗪对葡萄糖耐量的影响可能随给药时间而变化。
