Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
J Org Chem. 2010 Jun 4;75(11):3923-6. doi: 10.1021/jo1006043.
Under Lewis acidic conditions using Hf(OTf)(4), the aminomethylation of an indole derivative with a typical N,O-acetal preferentially produced kinetically favored N-aminomethylated indole derivatives instead of thermodynamically favored 3-aminomethylated indoles.
在路易斯酸性条件下，使用 Hf(OTf)(4)，吲哚衍生物与典型的 N,O-缩醛的氨甲基化优先产生动力学上有利的 N-氨甲基吲哚衍生物，而不是热力学上有利的 3-氨甲基吲哚。
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