Centro de Investigación Hospital Universitario 12 de Octubre, Madrid, España.
Eur J Clin Invest. 2010 Jun;40(6):511-7. doi: 10.1111/j.1365-2362.2010.02291.x. Epub 2010 Apr 26.
Iron is essential for mammalian metabolism and its cellular concentration is controlled by regulating its acquisition and storage. Haemochromatosis is a condition involving iron overload that is characterised by increased duodenal iron absorption and a progressive accumulation of iron in vital organs. Hepcidin is the main hormone that regulates iron homoestasis and it is secreted by the liver.
We have studied how extended hepcidin administration affects the iron load status, plasma and tissue iron concentration, erythropoiesis and the expression of proteins involved on iron homeostasis in haemochromatotic (Hfe(-/-)) and wild-type mice.
Hepcidin reverted the high plasma iron concentrations in Hfe(-/-) mice to normal values. The high concentration of hepatic iron was not altered in the liver of these Hfe(-/-) mice. Hepcidin administration did not disturb erythropoiesis in either Hfe(-/-) or wild-type mice and likewise, hepcidin did not modify the expression of any protein analysed in the liver, duodenum or spleen of Hfe(-/-) and wild-type mice. These data confirm that hepcidin administration diminishes plasma iron concentrations.
Treatment with sustained doses of hepcidin diminishes plasma iron concentrations in Hfe(-/-) mice.
铁是哺乳动物代谢所必需的，其细胞浓度受其获取和储存的调节。血色病是一种铁过载的情况，其特征是十二指肠铁吸收增加和重要器官中铁的逐渐积累。铁调素是调节铁稳态的主要激素，由肝脏分泌。
我们研究了延长铁调素给药如何影响血色病（Hfe(-/-)）和野生型小鼠的铁负荷状态、血浆和组织铁浓度、红细胞生成以及铁稳态相关蛋白的表达。
铁调素将 Hfe(-/-) 小鼠的高血浆铁浓度恢复到正常水平。这些 Hfe(-/-) 小鼠的肝脏中铁含量没有改变。铁调素给药不会干扰 Hfe(-/-) 或野生型小鼠的红细胞生成，同样，铁调素也不会改变 Hfe(-/-) 和野生型小鼠肝脏、十二指肠或脾脏中分析的任何蛋白的表达。这些数据证实铁调素给药可降低血浆铁浓度。
持续给予铁调素可降低 Hfe(-/-) 小鼠的血浆铁浓度。
