Laoubi K, Allanore Y, Chaussade S, Kahan A, Wipff J
Service de rhumatologie A, hôpital Cochin, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
J Mal Vasc. 2010 Jul;35(4):250-3. doi: 10.1016/j.jmv.2010.03.009. Epub 2010 Apr 24.
Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular involvement, which very frequently targets the digestive tract. Gastrointestinal involvement is noted in up to 90% of cases, the segment most frequently involved being the esophagus although the entire digestive tract may be affected. Gastroesophageal reflux is the most common symptom but other unusual complications may also occur. Gastric antral vascular ectasia (GAVE) or watermelon stomach is one such rare lesion; it relates to a disturbed capillary bed, which appears dilated, sometimes with thrombi under the mucosa. This lesion is one expression of generalized SSc microvasculopathy. Its prevalence is not precisely known but appears to be weak; however, it remains a cause of anemia clinicians should be aware of. Indeed, specific local treatment must be delivered and is usually efficient despite frequent recurrent events.
系统性硬化症（SSc）是一种以微血管受累为特征的结缔组织疾病，消化道是其常见的受累靶器官。高达90%的患者存在胃肠道受累，最常受累的部位是食管，不过整个消化道都可能受到影响。胃食管反流是最常见的症状，但也可能出现其他不寻常的并发症。胃窦血管扩张症（GAVE）或西瓜胃就是这样一种罕见病变；它与紊乱的毛细血管床有关，毛细血管床呈扩张状态，有时黏膜下还有血栓形成。这种病变是系统性硬化症微血管病变的一种表现形式。其患病率尚不清楚，但似乎较低；然而，它仍是临床医生应予以关注的贫血病因。实际上，必须进行特定的局部治疗，尽管病情常反复，但通常有效。
